Ronco E, Migueres M L, Vacheron F, Guenounou M
Laboratoire de Bactériologie, Hôpital R. Poincaré, Garches.
Pathol Biol (Paris). 1988 May;36(5):430-4.
We studied the susceptibility of Enterobacteriaceae to four aminoglycosides (gentamicin, tobramycin, netilmicin et amikacin). We determined their phenotypes of resistance by taking into account both the critic concentrations of the CFA (french committee for antibiogram) and the MIC of the main susceptible population of each species. The most frequent phenotypes were GTNt, TNtA and GTNtA. Amikacin resistance including phenotypes were essentially found in Klebsiella and Serratia (35% and 53% of the strains, respectively); with respect to amikacin, the phenotype expression may be insufficient to exceed the sensitive critic concentration of the CFA. Amikacin resistant strains were isolated from chronically infected patients with devices, such as urinary catheters or tracheal cannula. These results suggest a strains or plasmids outbreak.
我们研究了肠杆菌科细菌对四种氨基糖苷类药物（庆大霉素、妥布霉素、奈替米星和阿米卡星）的敏感性。我们通过考虑法国抗菌谱委员会（CFA）的临界浓度以及每个菌种主要敏感群体的最低抑菌浓度（MIC）来确定它们的耐药表型。最常见的表型是GTNt、TNtA和GTNtA。包括这些表型在内的阿米卡星耐药主要见于克雷伯菌属和沙雷菌属（分别占菌株的35%和53%）；就阿米卡星而言，表型表达可能不足以超过CFA的敏感临界浓度。耐阿米卡星菌株从长期感染器械（如导尿管或气管插管）的患者中分离得到。这些结果提示存在菌株或质粒的暴发。
