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[细胞色素P-450亚家族CYP2D、CYP2E和CYP3A某些基因多态性的临床意义——第二部分]

[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

作者信息

Wojtczak Anna, Skretkowicz Jadwiga

机构信息

Medical University of Łódź, Department of Pharmacogenetics, Poland.

出版信息

Pol Merkur Lekarski. 2009 Aug;27(158):166-9.

PMID:19856888
Abstract

Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.

摘要

从药物治疗的有效性和安全性以及某些疾病风险增加的角度来看，药物生物转化的多态性具有临床意义。本文介绍了细胞色素P-450（CYP）外源性物质代谢酶的几种基因多态性的分子机制和临床意义，以及某些疾病发生的遗传易感性。

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[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].[细胞色素P-450亚家族CYP2D、CYP2E和CYP3A某些基因多态性的临床意义——第二部分]
Pol Merkur Lekarski. 2009 Aug;27(158):166-9.
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[Clinical significance of some genetic polymorphisms of cytochrome P-450: family CYP1 and subfamilies CYP2A, CYP2B and CYP2C].细胞色素P-450某些基因多态性的临床意义：CYP1家族及CYP2A、CYP2B和CYP2C亚家族
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Mol Genet Genomic Med. 2019 Jun;7(6):e669. doi: 10.1002/mgg3.669. Epub 2019 Apr 25.
2
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.CYP3A5*3 和 MDR1 C3435T 多态性与儿童和青少年耐药性癫痫的预后相关。
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