Zhang Zhongbin, Xia Zhaolin
School of Public Health, Fudan University, Shanghai 200032, China.
Wei Sheng Yan Jiu. 2003 Jul;32(4):402-5.
The response of the individuals to xenobiotics is various due to the genetic polymorphism, that is, most likely, the determinant factor of the susceptibility of the individuals to xenobiotics. Therefore, the risk of diseases taking cancers as an example is different in population. In this paper, progresses of genetic polymorphism of toxicant-metabolizing enzyme genes and DNA repair genes and, their effects on individuals' risk to diseases were briefly reviewed.
由于基因多态性，个体对外源化学物的反应各不相同，这很可能是个体对外源化学物易感性的决定性因素。因此，以癌症为例，不同人群患疾病的风险也不同。本文简要综述了毒物代谢酶基因和DNA修复基因的基因多态性研究进展及其对个体疾病风险的影响。
