Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, Kentucky 40506, USA.
ACS Nano. 2009 Nov 24;3(11):3475-84. doi: 10.1021/nn901082u.
How to lay down nanowires at designated positions is a challenge that undermines the development of nanowire-based devices. We demonstrate that aptamer fibers, which are formed by the self-assembly of multiple aptamers, anchor specifically on the edge of protein patterns. This edge-anchoring effect originates from the biospecific recognition between the aptamer and its target protein. The fractal- shaped aptamer fibers are 1-6 nm high and can be tens of micrometers long. Once these edge-bound fibers have formed, they can serve as scaffolds for further assembly processes. We used these aptamer fibers as templates to fabricate palladium and streptavidin nanowires, which anchored on the pattern edges and never cross over or collapse over each other. The aptamer fiber scaffold provides a solution for fabricating and interfacing nanowires to existing surface patterns.
如何将纳米线定位在指定位置是阻碍基于纳米线器件发展的一个挑战。我们证明，由多个适体自组装形成的适体纤维特异性地锚定于蛋白质图案的边缘。这种边缘固定效应源于适体与其靶蛋白之间的生物特异性识别。分形形状的适体纤维高 1-6nm，长度可达数十微米。一旦形成这些边缘结合的纤维，它们就可以作为进一步组装过程的支架。我们使用这些适体纤维作为模板来制造钯和链霉亲和素纳米线，它们锚定在图案边缘，从不相互交叉或坍塌。适体纤维支架为制造和连接纳米线到现有表面图案提供了一种解决方案。
