用于制备巴豆烷二萜的高度官能化环戊烷片段的一般合成方法。
General synthesis of highly functionalized cyclopentane segments for the preparation of jatrophane diterpenes.
机构信息
Institute of Organic Chemistry, University of Vienna, Wahringerstrasse 38, A-1090 Vienna, Austria.
出版信息
Org Lett. 2009 Nov 19;11(22):5326-8. doi: 10.1021/ol902221y.
PMID:19856927
Abstract
Short and efficient syntheses of two diastereomeric cyclopentane segments present in most jatrophane diterpenes were achieved. Key steps are a stereoselective C-2 elongation, an RCM, and a hydroboration reaction. An orthogonal protecting group methodology makes these segments useful building blocks for diterpene synthesis.
摘要
实现了大多数大戟烷二萜中存在的两个非对映异构环戊烷片段的短捷高效合成。关键步骤是立体选择性的 C-2 延伸、RCM 和硼氢化反应。正交保护基方法使这些片段成为二萜合成的有用构建块。
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