（-）-海鞘素 A 的全合成。
Total synthesis of (-)-crinipellin A.
机构信息
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon, 305-701, Korea.
出版信息
J Am Chem Soc. 2014 Jul 23;136(29):10274-6. doi: 10.1021/ja5054412. Epub 2014 Jul 10.
PMID:25003871
Abstract
The first total synthesis of (-)-crinipellin A is described. The tetraquinane core skeleton of crinipellin A was assembled through the tandem [2 + 3] cycloaddition reaction of an allenyl diazo substrate containing a cyclopentane ring in a single operation. The absolute stereochemistry was confirmed through the total synthesis.
摘要
本文描述了 (-)-crinipellin A 的首次全合成。通过含环戊烷的烯丙基重氮底物的串联 [2 + 3] 环加成反应，在一步反应中构建了 crinipellin A 的四环烷核心骨架。通过全合成确定了绝对立体化学。
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