Faculté de Pharmacie, UMR 7200, CNRS-Université de Strasbourg, Laboratoire d'Innovation Thérapeutique, 74 route du Rhin, F-67401 Illkirch, France.
Org Lett. 2009 Nov 19;11(22):5314-7. doi: 10.1021/ol902279m.
A multicomponent reaction between H(2), CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using pi-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
已经发现了 H(2)、CO、不饱和羧酸衍生物和双亲核试剂之间的多组分反应。这个过程代表了多样性导向合成和多组分反应的结合，包括酰胺化和氢甲酰化，然后是亲核加成到 N-酰亚胺离子上，从而生成六个新的键。使用π-亲核试剂，该序列就变成了多组分 Pictet-Spengler 反应。
