Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
J Med Food. 2009 Oct;12(5):1127-35. doi: 10.1089/jmf.2008.0219.
The physicochemical properties of the oil from the fruit of Blighia sapida and the toxicological effect of the oil-based diet on some biochemical parameters of selected rat tissues and serum were studied. The smoke, flash, and fire points as well as peroxide, iodine, and acid values of the fruit oil were significantly lower (P < .05), whereas the specific gravity, relative density, saponification, and ester values compared well with soybean oil. The fruit oil yield was 20.02%. The oil consisted of 22.22% saturated, 56.43% monounsaturated, and 21.35% polyunsaturated fatty acids. It is richer than soybean oil in behenic, palmitoleic, oleic, gadoleic, erucic, and 9,12-eicosanoic acids by 15.70%, 0.89%, 7.22%, 12.05%, 8.27%, and 21.35%, respectively. The liver- and kidney-body weight ratios as well as the serum concentrations of cholesterol and high-density lipoprotein cholesterol of the rats maintained on diet formulated with the oil from the fruit of B. sapida increased significantly (P < .05), but the triglyceride and atherogenic index decreased (P < .05). The low-density lipoprotein cholesterol concentration and the heart-body weight ratio of the rats fed with the fruit oil diet compared well (P > .05) with those on soybean oil-based diet. Animals fed with the fruit oil-based diet had their activities of liver glutamate oxaloacetate transaminase and glutamate pyruvate transaminase as well as alkaline phosphatase activities of the liver and kidney decreased with corresponding increase in the serum enzymes. These results suggest that oil from B. sapida fruit could be edible and may be explored as raw materials in the paint, margarine, and soap industries. The oil is also unlikely to predispose the animals to cardiovascular risk, but may labilize the plasma membrane of the hepatocytes and nephrons. It may also have a negative effect on the metabolism and regulation of amino acid in the animals. Therefore, the oil from B. sapida fruit may not be completely safe for consumption.
研究了 Blighia sapida 果实油的物理化学性质以及基于该油的饮食对选定大鼠组织和血清中一些生化参数的毒理学影响。该果实油的烟点、闪点和燃点以及过氧化物值、碘值和酸值均显著降低（P<.05），而比重、相对密度、皂化值和酯值与大豆油相当。该果实油的产率为 20.02%。油中含有 22.22%的饱和脂肪酸、56.43%的单不饱和脂肪酸和 21.35%的多不饱和脂肪酸。与大豆油相比，该油中分别含有 15.70%、0.89%、7.22%、12.05%、8.27%和 21.35%的山嵛酸、棕榈油酸、油酸、麻疯树酸、芥酸和 9,12-二十碳二烯酸，含量更丰富。用 Blighia sapida 果实油配制的饮食喂养的大鼠的肝体比和肾体比以及血清胆固醇和高密度脂蛋白胆固醇浓度显著升高（P<.05），但甘油三酯和动脉粥样硬化指数降低（P<.05）。用果实油喂养的大鼠的低密度脂蛋白胆固醇浓度和心脏体比与用大豆油喂养的大鼠相比无显著差异（P>.05）。用果实油喂养的动物的肝脏谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶以及肝脏和肾脏的碱性磷酸酶活性降低，相应的血清酶活性增加。这些结果表明，Blighia sapida 果实油可食用，并可作为油漆、人造黄油和肥皂工业的原料进行开发。该油也不太可能使动物易患心血管疾病风险，但可能使肝细胞和肾单位的质膜不稳定。它还可能对动物的氨基酸代谢和调节产生负面影响。因此，Blighia sapida 果实油的食用并不完全安全。
