Ide Toshimitsu, Kamijo Yoshito
Department of Neurology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Am J Emerg Med. 2009 Oct;27(8):992-6. doi: 10.1016/j.ajem.2008.07.009.
This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE).
Nine patients with CO poisoning were included in the study. Cerebrospinal fluid was sampled within 24 hours of the last exposure to CO, on hospital day 4, and once a week for at least 1 month to determine IL-6 and myelin basic protein concentrations. All patients were followed at least 3 months.
Three patients demonstrated significant early IL-6 elevation in CSF, normal IL-6 level in CSF on day 4, and significant delayed myelin basic protein elevation in CSF. The 2 patients with the highest early IL-6 elevation in CSF developed DE. Interleukin 6 in serum was not related to DE.
Interleukin 6 in CSF at the early phase of CO poisoning may be a predictive marker of DE.
本研究旨在调查一氧化碳（CO）中毒早期脑脊液（CSF）中的白细胞介素6（IL-6）是否可作为迟发性脑病（DE）的预测标志物。
9例CO中毒患者纳入本研究。在最后一次接触CO后24小时内、住院第4天以及至少1个月内每周采集一次脑脊液，以测定IL-6和髓鞘碱性蛋白浓度。所有患者均随访至少3个月。
3例患者脑脊液中IL-6早期显著升高，第4天脑脊液中IL-6水平正常，脑脊液中髓鞘碱性蛋白显著延迟升高。脑脊液中早期IL-6升高最高的2例患者发生了DE。血清中的白细胞介素6与DE无关。
CO中毒早期脑脊液中的白细胞介素6可能是DE的预测标志物。
