嗜盐菌电机开关复合模型的稳态相分布。

The steady-state phase distribution of the motor switch complex model of Halobacterium salinarum.

机构信息

Max Planck Institute of Biochemistry, Department of Membrane Biochemistry, 82152 Martinsried, Germany.

出版信息

Math Biosci. 2009 Dec;222(2):117-26. doi: 10.1016/j.mbs.2009.10.002. Epub 2009 Oct 24.

DOI:10.1016/j.mbs.2009.10.002

PMID:19857501

Abstract

Steady-state analysis is performed on the kinetic model for the switch complex of the flagellar motor of Halobacterium salinarum (Nutsch et al.). The existence and uniqueness of a positive steady-state of the system is established and it is demonstrated why the steady-state is centered around the competent phase, a state of the motor in which it is able to respond to light stimuli. It is also demonstrated why the steady-state shifts to the refractory phase when the steady-state value of the response regulator CheYP increases. This work is one aspect of modeling in systems biology wherein the mathematical properties of a model are established.

摘要

对嗜盐菌鞭毛马达开关复合物的动力学模型进行了稳态分析（Nutsch 等人）。建立了系统正稳态的存在性和唯一性，并证明了为什么稳态集中在有能力的阶段，这是马达能够响应光刺激的状态。还证明了当响应调节剂 CheYP 的稳态值增加时，为什么稳态会转移到不应期阶段。这项工作是系统生物学建模的一个方面，其中建立了模型的数学性质。