迈向癌症的分子分类。

Toward a molecular classification of cancer.

机构信息

University of Cincinnati Academic Health Center, College of Pharmacy, Cincinnati, OH 5267-0004, USA.

出版信息

Toxicology. 2010 Dec 5;278(2):195-8. doi: 10.1016/j.tox.2009.10.016. Epub 2009 Oct 24.

DOI:10.1016/j.tox.2009.10.016

PMID:19857539

Abstract

The diagnosis of cancer is typically made on the basis of clinical and histological criteria. However, molecular biology research over the past three decades has revealed that diagnoses based on clinical presentation and pathology evaluation are not always accurate. With the advent of molecularly targeted drugs, a reclassification of cancers, based on their underlying genetic defects, is becoming increasingly urgent.

摘要

癌症的诊断通常基于临床和组织学标准。然而，过去三十年来的分子生物学研究表明，基于临床表现和病理评估的诊断并不总是准确的。随着分子靶向药物的出现，基于潜在遗传缺陷对癌症进行重新分类变得越来越迫切。