University of Cincinnati Academic Health Center, James L. Winkle College of Pharmacy, 3225 Eden Avenue, Cincinnati, OH 45267-0004, USA.
Br J Cancer. 2010 Sep 7;103(6):861-9. doi: 10.1038/sj.bjc.6605834.
Only a fraction of molecular cancer markers identified in the scientific literature have found clinical use. Specifically, few predictors of invasiveness are established in diagnostics. Meta-analysis is a valuable tool for biomarker validation. Here, we evaluate Osteopontin as a marker for tumor aggressiveness (grade, stage, early progression) and patient survival.
Publications through 2008 with the keywords 'osteopontin AND cancer' were retrieved. Titles and abstracts were screened for studies presenting original data on human subjects. This left 228 publications for data extraction. We applied categorical data analysis for testing the relationship between Osteopontin and a clinical variable.
Osteopontin ranks correlated with lower overall and disease-free/relapse-free survival in all tumors combined, as well as in lung cancer, breast cancer, prostate cancer, head and neck cancer, and liver cancer. Further, Osteopontin levels correlated with tumor grade and stage for all tumors combined and for several individual tumor types. Osteopontin levels were significantly associated with the early progression of eight cancers, independent in one, and inversely correlated in two.
Osteopontin is significantly associated with survival in several forms of cancer. Osteopontin levels are also markers for stage, grade, and early tumor progression in multiple cancers, reflecting a common molecular underpinning for distinct clinical measures. Osteopontin has value as a clinical tumor progression marker.
只有一小部分在科学文献中鉴定出的分子癌症标志物在临床上得到了应用。具体来说，在诊断中很少有侵袭性的预测因子得到建立。荟萃分析是验证生物标志物的一种有价值的工具。在这里，我们评估骨桥蛋白作为肿瘤侵袭性（分级、分期、早期进展）和患者生存的标志物。
通过 2008 年的关键词“骨桥蛋白和癌症”检索文献。对标题和摘要进行筛选，以获取关于人类受试者的原始数据的研究。这留下了 228 篇用于数据提取的出版物。我们应用分类数据分析来检验骨桥蛋白与临床变量之间的关系。
骨桥蛋白等级与所有肿瘤的总生存率和无病/无复发生存率相关，与肺癌、乳腺癌、前列腺癌、头颈部癌和肝癌相关。此外，骨桥蛋白水平与所有肿瘤的分级和分期以及一些个别肿瘤类型相关。骨桥蛋白水平与八种癌症的早期进展显著相关，在一种癌症中独立相关，在两种癌症中呈负相关。
骨桥蛋白与多种癌症的生存显著相关。骨桥蛋白水平也是多种癌症的分期、分级和早期肿瘤进展的标志物，反映了不同临床指标的共同分子基础。骨桥蛋白作为临床肿瘤进展标志物具有一定的价值。
