Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2009 Nov;25(11):588-95. doi: 10.1016/S1607-551X(09)70561-3.
Recent longitudinal experiences have emphasized that the follow-up of children with treated congenital hypothyroidism (CHT) should not be limited to the cognitive domain. This study attempted to evaluate the emotional-behavioral profiles in children with CHT together with maternal parenting stress profiles. Data for child and family characteristics were collected from 47 families with a 3-12-year-old CHT child diagnosed and treated since the newborn period. Cognitive assessments were performed. The main caregiver completed the following questionnaires: (1) Strengths and Difficulties Questionnaire, which rated behavioral symptoms in children; (2) Parenting Stress Index, which determined the quality and magnitude of parenting stress experienced by the caregiver; and (3) Symptom Checklist-90-R, which evaluated the psychopathological symptoms of the caregiver. In addition, 31 unaffected siblings were recruited as a comparative control group. The results revealed that children with treated CHT had normal intelligence quotients (mean, 93.6 +/- 16.2) at the time of the study. However, CHT children had more problems in emotional-behavioral domains than sibling controls (p = 0.01). Overall, 29.8% (14/47) of the CHT children had emotional-behavioral problems above the clinical cutoff. In addition, 13% of the caregivers of CHT children had parenting stress above the clinical cutoff. Therefore, professional intervention is warranted in these subgroups of CHT children and parents.
最近的纵向研究经验强调，治疗先天性甲状腺功能减退症（CHT）儿童的随访不应仅限于认知领域。本研究试图评估 CHT 儿童的情绪-行为特征以及母亲的育儿压力特征。从 47 个有 3-12 岁 CHT 儿童的家庭中收集了儿童和家庭特征的数据，这些儿童在新生儿期就被诊断和治疗。进行了认知评估。主要照顾者完成了以下问卷：（1）长处和困难问卷，评估儿童的行为症状；（2）育儿压力指数，确定照顾者经历的育儿压力的质量和程度；（3）症状清单-90-R，评估照顾者的心理病理症状。此外，还招募了 31 名未受影响的兄弟姐妹作为对照组。结果表明，在研究时，接受治疗的 CHT 儿童的智商正常（平均值为 93.6 +/- 16.2）。然而，CHT 儿童在情绪-行为领域的问题比兄弟姐妹对照组更多（p = 0.01）。总体而言，47 名 CHT 儿童中有 29.8%（14/47）的儿童存在情绪-行为问题超过临床临界值。此外，13%的 CHT 儿童的照顾者存在育儿压力超过临床临界值。因此，这些 CHT 儿童和父母的亚组需要专业干预。
