Karmonik C, Diaz O, Grossman R, Klucznik R
Radiology, The Methodist Hospital Research Institute, Houston, TX, USA.
Rofo. 2010 Feb;182(2):140-50. doi: 10.1055/s-0028-1109670. Epub 2009 Oct 26.
The quantification of wall motion in cerebral aneurysms is of interest for the assessment of aneurysmal rupture risk, for providing boundary conditions for computational simulations and as a validation tool for theoretical models.
2D cine phase contrast magnetic resonance imaging (2D pcMRI) in combination with quantitative magnetic resonance angiography (QMRA) was evaluated for measuring wall motion in 7 intracranial aneurysms. In each aneurysm, 2 (in one case 3) cross sections, oriented approximately perpendicular to each other, were measured.
The maximum aneurysmal wall distention ranged from 0.16 mm to 1.6 mm (mean 0.67 mm), the maximum aneurysmal wall contraction was -1.91 mm to -0.34 mm (mean 0.94 mm), and the average wall displacement ranged from 0.04 mm to 0.31 mm (mean 0.15 mm). Statistically significant correlations between average wall displacement and the shape of inflow curves (p-value < 0.05) were found in 7 of 15 cross sections; statistically significant correlations between the displacement of the luminal boundary center point and the shape of inflow curves (p-value < 0.05) were found in 6 of 15 cross sections.
2D pcMRI in combination with QMRA is capable of visualizing and quantifying wall motion in cerebral aneurysms. However, application of this technique is currently restricted by its limited spatial resolution.
量化脑动脉瘤壁运动对于评估动脉瘤破裂风险、为计算模拟提供边界条件以及作为理论模型的验证工具具有重要意义。
评估二维电影相位对比磁共振成像（2D pcMRI）结合定量磁共振血管造影（QMRA）测量7个颅内动脉瘤壁运动的情况。在每个动脉瘤中，测量2个（1例为3个）大致相互垂直的横截面。
最大动脉瘤壁扩张范围为0.16毫米至1.6毫米（平均0.67毫米），最大动脉瘤壁收缩为-1.91毫米至-0.34毫米（平均0.94毫米），平均壁位移范围为0.04毫米至0.31毫米（平均0.15毫米）。在15个横截面中的7个发现平均壁位移与流入曲线形状之间存在统计学显著相关性（p值<0.05）；在15个横截面中的6个发现管腔边界中心点位移与流入曲线形状之间存在统计学显著相关性（p值<0.05）。
2D pcMRI结合QMRA能够可视化和量化脑动脉瘤壁运动。然而，该技术目前因其有限的空间分辨率而受到应用限制。
