Yokoyama Tomohisa, Ohyashiki Kazuma
Department of Clinical Oncology, Tokyo Medical University.
Nihon Rinsho. 2009 Oct;67(10):1869-74.
Leukemogenesis is thought to be a multistep process involving changes in the expression or abnormalities in the function of proteins encorded by a number of genes within the same cell. Such abnormalities affect the balance among cell proliferation, differentiation, and programmed cell death (PCD), and this lead to an expansion of the malignant clone. Apoptosis (type I PCD) and autophagy (type II PCD) are any form of cell death, mediated by an intracellular program, and involved in cell homeostasis. However, the mechanism of apoptosis and autophagy is extremely complex in leukemia cells, and the molecular machinery is still obscure. Therefore, understanding the regulation of apoptotic and autophagic signaling pathways could provide important information for the development of novel therapies in leukemia cells.
白血病发生被认为是一个多步骤过程，涉及同一细胞内多个基因所编码蛋白质的表达变化或功能异常。这些异常影响细胞增殖、分化和程序性细胞死亡（PCD）之间的平衡，进而导致恶性克隆的扩增。凋亡（I型PCD）和自噬（II型PCD）是由细胞内程序介导的任何形式的细胞死亡，参与细胞稳态。然而，白血病细胞中凋亡和自噬的机制极其复杂，分子机制仍不清楚。因此，了解凋亡和自噬信号通路的调控可为白血病细胞新疗法的开发提供重要信息。
