Handa A
1st Department of Internal Medicine, Saitama Medical School.
Nihon Rinsho. 1996 Jul;54(7):1797-802.
It is clear that cytokines regulate normal hematopoiesis including proliferation, differentiation, and apoptosis (programmed cell death). Leukemia is a disorder of unbalance between excessive proliferation and inappropriate apoptosis. Leukemic cells are also stimulated by cytokines similar to normal hematopoietic cells. It is reported that the oncogenes and tumor suppressor genes are associated with not only leukemogenesis but also cell cycle, for example proliferation, differentiation, and apoptosis (programmed cell death). We found that G-CSF leads to apoptosis of radiation induced murine leukemia cell line (C2M-A5), and its apoptosis is dependent on cell cycle. From these results together with other related reports, cytokines seem to be a key substance of apoptosis of leukemic cells and the apoptosis inducing therapy will be a new strategy for leukemia therapy.
很明显，细胞因子调节正常造血过程，包括增殖、分化和凋亡（程序性细胞死亡）。白血病是过度增殖与不适当凋亡之间失衡的一种病症。白血病细胞也受到与正常造血细胞类似的细胞因子的刺激。据报道，癌基因和肿瘤抑制基因不仅与白血病发生有关，还与细胞周期有关，例如增殖、分化和凋亡（程序性细胞死亡）。我们发现粒细胞集落刺激因子（G-CSF）可导致辐射诱导的小鼠白血病细胞系（C2M-A5）凋亡，且其凋亡依赖于细胞周期。结合这些结果以及其他相关报道来看，细胞因子似乎是白血病细胞凋亡的关键物质，而诱导凋亡疗法将成为白血病治疗的一种新策略。
