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孕期复杂胆结石疾病的管理

Management of complicated gallstone disease during pregnancy.

作者信息

Al-Akeely Mohammed Hamad

机构信息

Department of Surgery, Riyadh Medical Complex, Riyadh, Saudi Arabia.

出版信息

Saudi J Gastroenterol. 2003 Sep;9(3):135-8.

Abstract

BACKGROUND

Controversy still exists regarding the optimal management of complicated gallstones during pregnancy owing to the possible risks for the fetus. Generally the management of such problems during pregnancy is conservative, however, endoscopic retrograde cholangiopancreatography (ERCP) and/or operative intervention may be required in some patients.

AIM OF STUDY

The aim is to evaluate the management of complicated gallstone disease with particular reference to the indications, timing and risks of ERCP and operative intervention during pregnancy and its effect on fetus outcome.

PATIENTS AND METHODS

This retrospective study was conducted on 32 pregnant women, who were admitted with complication of cholelithiasis at Riyadh Medical Complex (RMC) through the emergency during the period of March 1998-October 2002. Their files were evaluated for age, presentation, gestational age, hematological, radiological, fetus assessment, management, fetus out come and how ERCP and surgery were performed.

RESULTS

Among the 32 pregnant women studied, 22 responded satisfactorily to conservative treatment. They had laparoscopic cholecystectomy (LC) after delivery. Ten patients needed further treatment, two were operated for acute cholecystitis (AC) and recurrent biliary colic (BC). Eight patients had ERCP for obstructive jaundice and recurrent pancreatitis following which two had LC cholecystectomy. All patients remained well until delivery.

CONCLUSION

Majority of gallstone complications during pregnancy can be managed conservatively. Surgery can be deferred until delivery. Few patients who needed ERCP and/or surgery can be managed safely during second and third trimester.

摘要

背景

由于对胎儿可能存在风险,妊娠期间复杂胆结石的最佳管理仍存在争议。一般来说,妊娠期间此类问题的管理是保守的,然而,一些患者可能需要内镜逆行胰胆管造影(ERCP)和/或手术干预。

研究目的

目的是评估复杂胆结石疾病的管理,特别提及妊娠期间ERCP和手术干预的适应症、时机和风险及其对胎儿结局的影响。

患者与方法

本回顾性研究对1998年3月至2002年10月期间在利雅得医疗中心(RMC)因胆石症并发症通过急诊入院的32名孕妇进行。评估她们的档案,包括年龄、临床表现、孕周、血液学、放射学、胎儿评估、管理、胎儿结局以及ERCP和手术的实施方式。

结果

在研究的32名孕妇中,22名对保守治疗反应满意。她们在分娩后进行了腹腔镜胆囊切除术(LC)。10名患者需要进一步治疗,2名因急性胆囊炎(AC)和复发性胆绞痛(BC)接受手术。8名患者因梗阻性黄疸和复发性胰腺炎接受ERCP,其中2名随后进行了LC胆囊切除术。所有患者直至分娩情况良好。

结论

妊娠期间大多数胆结石并发症可保守治疗。手术可推迟至分娩后。少数需要ERCP和/或手术的患者在孕中期和孕晚期可安全治疗。

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