Grandt D
Institut für Arzneitherapiesicherheit, fUniversitätsklinikum Essen und Klinikum Saarbrücken, Winterberg 1, 66119, Saarbrücken, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Dec;52(12):1161-5. doi: 10.1007/s00103-009-0975-5.
Drug treatment is beneficial in most patients but can also cause adverse events and death. Since preventable adverse drug events are a relevant cause of morbidity and mortality, strategies for improving medication safety are warranted. Studies demonstrate that system failure is the most relevant cause of preventable adverse drug events, with prescribing errors being the most relevant. Lack of information either about the patient, the functioning of a patient's organs and concurrent medications, or about the prescribed drug, its correct dosing, contraindications and drug interactions often lead to preventable adverse drug events. International studies show that medication errors result in more people dying than from traffic accidents. Therefore, in addition to the safety of the drug, it is necessary that the safety of the process of drug treatment must be taken care of. This is called medicine safety. In order to improve medicine safety, it is necessary to consider the organization of the medication process, instead of looking for an individual to blame. The goal of the "Action Plan for Medication Safety in Germany" ("Aktionsplan Arzneimitteltherapiesicherheit für Deutschland") from the Federal Ministry of Health is to optimize patient safety in drug treatment by the joint efforts of physicians, pharmacists, patients, and politicians.
药物治疗对大多数患者有益,但也可能导致不良事件和死亡。由于可预防的药物不良事件是发病和死亡的一个相关原因,因此有必要采取提高用药安全性的策略。研究表明,系统故障是可预防药物不良事件的最相关原因,其中处方错误最为突出。缺乏有关患者、患者器官功能和同时服用药物的信息,或者缺乏有关所开药物、其正确剂量、禁忌症和药物相互作用的信息,往往会导致可预防的药物不良事件。国际研究表明,用药错误导致死亡的人数比交通事故造成的死亡人数更多。因此,除了药物的安全性外,药物治疗过程的安全性也必须得到保障。这被称为用药安全。为了提高用药安全,有必要考虑用药过程的组织安排,而不是寻找个人来归咎。德国联邦卫生部的《德国用药安全行动计划》的目标是通过医生、药剂师、患者和政治家的共同努力,优化药物治疗中的患者安全。