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咖啡因诱导γ射线照射的HeLa细胞存活率降低以及大肠杆菌RecA蛋白对咖啡因效应的逆转。

Caffeine-induced reduction of the survival of gamma-irradiated HeLa cells and the reversal of the caffeine effect by Escherichia coli RecA protein.

作者信息

Spivak I M, Kostetsky I E, Shpielevaya S P, Kordyum V A, Zhestyanikov V D

机构信息

Institute of Cytology, Academy of Sciences, U.S.S.R., Leningrad.

出版信息

Mutat Res. 1991 Jan;246(1):103-7. doi: 10.1016/0027-5107(91)90111-z.

DOI:10.1016/0027-5107(91)90111-z
PMID:1986256
Abstract

It is confirmed that survival of gamma-irradiated HeLa cells is decreased by post-treatment with caffeine. The caffeine effect is believed to be the result of an inhibition of the repair of gamma-ray-induced DNA damage. In this work we show that the caffeine-induced reduction of the survival of gamma-irradiated HeLa cells is reversed when Escherichia coli RecA protein is introduced into the cells with the aid of liposomes.

摘要

已证实，经咖啡因后处理会降低经伽马射线照射的海拉细胞的存活率。咖啡因的作用被认为是抑制伽马射线诱导的DNA损伤修复的结果。在这项工作中，我们表明，当借助脂质体将大肠杆菌RecA蛋白引入细胞时，咖啡因诱导的经伽马射线照射的海拉细胞存活率降低的情况会得到逆转。

相似文献

1
Caffeine-induced reduction of the survival of gamma-irradiated HeLa cells and the reversal of the caffeine effect by Escherichia coli RecA protein.咖啡因诱导γ射线照射的HeLa细胞存活率降低以及大肠杆菌RecA蛋白对咖啡因效应的逆转。
Mutat Res. 1991 Jan;246(1):103-7. doi: 10.1016/0027-5107(91)90111-z.
2
[The restoration by Escherichia coli RecA protein of the survival of gamma-irradiated HeLa cells reduced by the DNA repair inhibitors caffeine and 3-aminobenzamide].[大肠杆菌RecA蛋白对经DNA修复抑制剂咖啡因和3-氨基苯甲酰胺处理后γ射线照射的HeLa细胞存活率的恢复作用]
Tsitologiia. 1991;33(2):103-9.
3
The effects of caffeine on the expression of potentially lethal and sublethal damage in gamma-irradiated cultured mammalian cells.咖啡因对经γ射线照射的培养哺乳动物细胞中潜在致死性损伤和亚致死性损伤表达的影响。
Radiat Res. 1979 May;78(2):312-6.
4
[Mechanisms of action of inhibitors of postradiation cell recovery. II. Suppression by caffeine and acriflavine of unscheduled DNA synthesis in uv-irradiated HeLa Zh-63 cells].[辐射后细胞恢复抑制剂的作用机制。II. 咖啡因和吖啶黄对紫外线照射的HeLa Zh-63细胞中DNA非预定合成的抑制作用]
Tsitologiia. 1974;16(7):868-73.
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[Rejoining of DNA double strand breaks in gamma-irradiated HeLa Zh-63 cells incubated in the presence of caffeine].[在咖啡因存在的情况下孵育的经γ射线照射的HeLa Zh - 63细胞中DNA双链断裂的重新连接]
Dokl Akad Nauk SSSR. 1976 Feb 21;226(6):1436-8.
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[Acid polypeptides as inhibitors of the repair of double-stranded DNA breaks induced by the gamma irradiation of HeLa cells].[酸性多肽作为HeLa细胞γ射线照射诱导的双链DNA断裂修复的抑制剂]
Dokl Akad Nauk SSSR. 1990;315(3):721-4.
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[Mechanism of action of inhibitors of postradiation recovery of cells. IV. Effect of caffeine and acriflavine on the unscheduled synthesis of DNA, induced by x- and gamma-irradiation in HeLa cells].[细胞辐射后恢复抑制剂的作用机制。IV. 咖啡因和吖啶黄对HeLa细胞中由X射线和γ射线诱导的DNA非预定合成的影响]
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The action of caffeine on X-irradiated HeLa cells. X. Depressed recovery from potentially lethal damage in cells containing 5-bromodeoxyuridine.咖啡因对经X射线照射的海拉细胞的作用。十、含5-溴脱氧尿苷的细胞中潜在致死损伤恢复的抑制情况
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Repair of DNA double-strand breaks in Escherichia coli cells requires synthesis of proteins that can be induced by UV light.大肠杆菌细胞中DNA双链断裂的修复需要合成可被紫外线诱导的蛋白质。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3450-3. doi: 10.1073/pnas.78.6.3450.
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Effect of protein synthesis inhibition on recovery of UV- and gamma-irridated Schizosaccharomyces pombe from repair inhibition by caffeine.
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