咖啡因诱导γ射线照射的HeLa细胞存活率降低以及大肠杆菌RecA蛋白对咖啡因效应的逆转。
Caffeine-induced reduction of the survival of gamma-irradiated HeLa cells and the reversal of the caffeine effect by Escherichia coli RecA protein.
作者信息
Spivak I M, Kostetsky I E, Shpielevaya S P, Kordyum V A, Zhestyanikov V D
机构信息
Institute of Cytology, Academy of Sciences, U.S.S.R., Leningrad.
出版信息
Mutat Res. 1991 Jan;246(1):103-7. doi: 10.1016/0027-5107(91)90111-z.
It is confirmed that survival of gamma-irradiated HeLa cells is decreased by post-treatment with caffeine. The caffeine effect is believed to be the result of an inhibition of the repair of gamma-ray-induced DNA damage. In this work we show that the caffeine-induced reduction of the survival of gamma-irradiated HeLa cells is reversed when Escherichia coli RecA protein is introduced into the cells with the aid of liposomes.
已证实，经咖啡因后处理会降低经伽马射线照射的海拉细胞的存活率。咖啡因的作用被认为是抑制伽马射线诱导的DNA损伤修复的结果。在这项工作中，我们表明，当借助脂质体将大肠杆菌RecA蛋白引入细胞时，咖啡因诱导的经伽马射线照射的海拉细胞存活率降低的情况会得到逆转。
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