CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands.
Qual Life Res. 2009 Dec;18(10):1321-9. doi: 10.1007/s11136-009-9548-1. Epub 2009 Oct 28.
Scores on quality of life (QOL) domains and facets are probably subject to fluctuations across time due to the course of breast cancer treatment. Existing QOL studies have been cross-sectional. Therefore, this prospective follow-up study examined whether QOL domains (physical health, psychological health, social relationships, and environment) and QOL facets contributed differentially across time to overall QOL in women with early stage breast cancer.
From the 608 participating women, 225 women had early stage breast cancer. Before diagnosis and 1, 3, 6, and 12 months after surgical treatment, women with early stage breast cancer were assessed on QOL (WHOQOL-100).
Psychological Health and Social Relationships were the QOL domains that contributed to overall QOL most consistently at the various time points. Physical Health appeared to be a contributor at all time points except 1 month after surgery. Environment contributed to a lesser extent to overall QOL compared with Physical Health, Psychological Health, and Social Relationships. Different facets contribute to overall QOL-dependent of particular measurement points. However, the facets Positive Feelings and Personal Relationships were important factors at almost all time points of maintaining a good overall QOL.
QOL domains and facets contributed differently to overall QOL at various time points across treatment in women with early stage breast cancer.
由于乳腺癌治疗过程的影响，生活质量（QOL）领域和方面的评分可能会随时间波动。现有的 QOL 研究都是横断面研究。因此，本前瞻性随访研究旨在探讨在早期乳腺癌女性中，QOL 领域（身体健康、心理健康、社会关系和环境）和 QOL 方面是否会随时间的推移对整体 QOL 产生不同的影响。
在 608 名参与的女性中，有 225 名女性患有早期乳腺癌。在诊断前以及手术治疗后 1、3、6 和 12 个月，早期乳腺癌女性使用 WHOQOL-100 评估 QOL。
心理健康和社会关系是在不同时间点对整体 QOL 贡献最一致的 QOL 领域。身体健康在除手术后 1 个月外的所有时间点似乎都是一个贡献因素。与身体健康、心理健康和社会关系相比，环境对整体 QOL 的贡献程度较小。不同的方面会根据特定的测量点对整体 QOL 产生影响。然而，积极的感觉和个人关系这两个方面在维持良好整体 QOL 的几乎所有时间点都是重要因素。
在早期乳腺癌女性的治疗过程中，不同的 QOL 领域和方面在不同的时间点对整体 QOL 有不同的影响。
