Department of Food Science, National Chiayi University, Chaiyi, Taiwan.
Mol Nutr Food Res. 2010 Feb;54(2):259-67. doi: 10.1002/mnfr.200900049.
Anti-cancer activities of resveratrol (3,4',5-trihydroxylstilbene) have attracted extensive research attention. Suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells achieved by oral administration of resveratrol was assessed in three separate experiments. Each mouse was challenged by tail vein injection with CT26 cells. Prior to challenge, 8-wk-old mice were fed with a basal diet and orally administered with resveratrol (30 mg/kg/2 days) eight or twelve times. After challenge, oral administration of resveratrol was continued until mice were sacrificed on day 20. As integrated from three experiments, 3.7% of the control mice (n=27) and 68.7% of the resveratrol-treated mice (n=26) exhibited free of metastasis. In a second study, 8-wk-old BALB/c mice were orally administered with resveratrol 12 times and challenged with CT26 cells for 100 days. All control mice died but 50% of the resveratrol-treated mice survived. The surviving mice were challenged with CT26 cells by hypodermic injection, fed with a basal diet for an additional 30 days, and sacrificed. Tumor lumps or nodules were not detected at the injection sites or in the lungs. This reveals that intrinsic vaccination-like defense has resulted from administration of resveratrol and challenge of tumor cells.
白藜芦醇（3,4',5-三羟基二苯乙烯）的抗癌活性引起了广泛的研究关注。通过对 CT26 结直肠腺癌细胞进行尾静脉注射，评估了白藜芦醇对 BALB/c 小鼠肺部转移的抑制作用，该实验共进行了三次。每只小鼠均通过尾静脉注射 CT26 细胞进行挑战。在挑战之前，将 8 周龄的小鼠用基础饮食喂养，并口服白藜芦醇（30mg/kg/2 天）8 或 12 次。在挑战后，继续口服白藜芦醇，直到第 20 天处死小鼠。从三次实验综合来看，对照组（n=27）中有 3.7%的小鼠和白藜芦醇处理组（n=26）中有 68.7%的小鼠未发生转移。在第二项研究中，8 周龄的 BALB/c 小鼠口服白藜芦醇 12 次，并在 100 天内用 CT26 细胞进行挑战。所有对照组小鼠均死亡，但 50%的白藜芦醇处理组小鼠存活。对存活的小鼠进行 CT26 细胞皮下注射，用基础饮食喂养 30 天，然后处死。在注射部位或肺部未检测到肿瘤块或结节。这表明，白藜芦醇的给药和肿瘤细胞的挑战导致了内在的疫苗样防御。
