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白藜芦醇对 4T1 小鼠乳腺癌细胞体内外转移的影响。

Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo.

机构信息

Department of Food Science and Nutrition, Dongseo University, Busan 617-716, Korea.

出版信息

Nutr Res Pract. 2012 Aug;6(4):294-300. doi: 10.4162/nrp.2012.6.4.294. Epub 2012 Aug 31.

DOI:10.4162/nrp.2012.6.4.294
PMID:22977682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3439572/
Abstract

We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 µmol/L) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 days. After resveratrol treatment, cell adhesion, wound migration, invasion, and MMP-9 activity were significantly decreased in a dose-dependent manner in 4T1 cells (P < 0.05). The numbers of pulmonary nodules were significantly decreased in mice fed the resveratrol (P < 0.05). The plasma MMP-9 activity was decreased in response to treatment with resveratrol in mice (P < 0.05). We conclude that resveratrol inhibits cancer metastasis both in vitro and in vivo, and this inhibition is likely due to the decrease in MMP-9 activity caused by resveratrol.

摘要

我们研究了白藜芦醇在体外和体内系统中对转移的影响。将 4T1 细胞在不同浓度（0-30µmol/L）的白藜芦醇存在下培养。对于实验性转移，BALB/c 小鼠经尾静脉注射 4T1 细胞，并口服不同浓度（0、100 或 200mg/kg 体重）的白藜芦醇 21 天。白藜芦醇处理后，4T1 细胞中的细胞黏附、伤口迁移、侵袭和 MMP-9 活性均呈剂量依赖性显著降低（P<0.05）。用白藜芦醇喂养的小鼠肺部结节数量显著减少（P<0.05）。白藜芦醇处理后小鼠血浆 MMP-9 活性降低（P<0.05）。我们得出结论，白藜芦醇在体外和体内均抑制癌症转移，这种抑制作用可能是由于白藜芦醇降低了 MMP-9 活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/2c174a6f156e/nrp-6-294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/f5b5b22d13db/nrp-6-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/c147306bc4ec/nrp-6-294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/2c174a6f156e/nrp-6-294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/f5b5b22d13db/nrp-6-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/c147306bc4ec/nrp-6-294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/3439572/2c174a6f156e/nrp-6-294-g003.jpg

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