School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
J Pharm Sci. 2010 Mar;99(3):1309-21. doi: 10.1002/jps.21913.
The feasibility of using pollen-shape carriers in dry powder inhalation is studied. Pollen-shape hydroxyapatite (HA) particles are synthesized with a geometric diameter range from 21.1 to 48.6 microm and effective density range from 0.21 to 0.41 g/cm(3). The flowability of the particles is characterized by the Carr's compressibility index (CI) and angle of slide (theta). The HA carriers are found to have better flowability than commonly used lactose (LA) carrier with similar size range. The HA carriers are also found to be capable of high drug attachment. The aerosolization and deposition properties of a model drug are compared using HA and LA as carriers. Results indicate that pollen-shape HA carriers have good potential to be used as drug carrier in dry powder inhalation. It can give higher drug emission and respirable fraction than traditional LA carriers.
研究了花粉形状载体在干粉吸入中的可行性。合成了具有从 21.1 到 48.6 微米的几何直径范围和从 0.21 到 0.41 克/厘米 3 的有效密度范围的花粉形状羟基磷灰石（HA）颗粒。通过 Carr 可压缩性指数（CI）和滑动角（theta）来表征颗粒的流动性。发现与具有相似粒径范围的常用乳糖（LA）载体相比，HA 载体具有更好的流动性。还发现 HA 载体能够实现高药物附着。使用 HA 和 LA 作为载体比较了模型药物的气溶胶化和沉积特性。结果表明，花粉形状的 HA 载体具有作为干粉吸入用药物载体的良好潜力。它可以比传统的 LA 载体产生更高的药物释放和可吸入分数。
