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中性粒细胞与哮喘。

Neutrophils and asthma.

作者信息

Monteseirín J

机构信息

Immunology and Allergy Service, University Hospital Virgen Macarena, Sevilla, Spain.

出版信息

J Investig Allergol Clin Immunol. 2009;19(5):340-54.

Abstract

Although eosinophilic airway inflammation is recognized as an important feature of some patients with chronic, stable asthma, evidence supports an important role for neutrophils in asthma. Neutrophils are the first cells recruited to the site of the allergic reaction. Their presence may influence clinical presentation and has been linked to the development of severe chronic asthma and sudden severe attacks. Neutrophils are eliminated by apoptosis during the resolution of the allergic response.

摘要

尽管嗜酸性气道炎症被认为是慢性稳定型哮喘患者的一个重要特征,但有证据支持中性粒细胞在哮喘中发挥重要作用。中性粒细胞是最早被招募到过敏反应部位的细胞。它们的存在可能会影响临床表现,并与严重慢性哮喘和突然严重发作的发生有关。在过敏反应消退过程中,中性粒细胞通过凋亡被清除。

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