Zhang Xiaoxiang, Teo Wan Teng, Chan Philip Wai Hong
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore.
Org Lett. 2009 Nov 5;11(21):4990-3. doi: 10.1021/ol901981s.
A method to prepare indenols efficiently by ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols is described. The reaction was accomplished in moderate to excellent yields and regioselectivity under mild conditions and offers a straightforward and convenient one step synthetic route to bioactive indenols and its derivatives.
描述了一种通过三氟甲磺酸镱（III）催化炔丙醇与酚的串联傅克烷基化/氢芳基化反应高效制备茚醇的方法。该反应在温和条件下以中等至优异的产率和区域选择性完成，为生物活性茚醇及其衍生物提供了一条直接且便捷的一步合成路线。
