Department of Hematology, Chang Zheng Hospital, The Second Affiliated Hospital of The Second Military Medical University, Shanghai 200003, China.
Leuk Lymphoma. 2009 Dec;50(12):2013-6. doi: 10.3109/10428190903324236.
POEMS syndrome, also known as Crow-Fukase syndrome, represents a rare multisystem syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Hypothyroidism is one of the common endocrine abnormalities which are central features of POEMS syndrome. The clinical data associated with the measurement of thyroid function and its clinical significance in POEMS syndrome is still rare. Herein, we report 24 cases with POEMS syndrome which were studied thyroid function and clinical manifestations and performed an associated analysis between hypothyroidism and edema/effusions. Of the 24 patients with POEMS syndrome, 17(70.8%) had a recognized hypothyroidism (including 11 clinical hypothyroidism and 6 subclinical hypothyroidism). Fourteen patients (58.3%) had some form of extravascular volume overload. In 14 patients with edema/effusions, 12 were diagnosed as having hypothyroidism. Hypothyroidism may be one of causes of edema/effusions. After thyroid hormone treatment and chemotherapy, symptoms of hypothyroidism and edema /effusions were improved greatly.
POEMS 综合征，又称 Crow-Fukase 综合征，是一种罕见的多系统综合征，其特征为多发性神经病、脏器肿大、内分泌病、M 蛋白和皮肤改变。甲状腺功能减退症是 POEMS 综合征常见的内分泌异常之一，也是其特征性表现之一。目前，关于 POEMS 综合征患者甲状腺功能的检测及其与临床意义的相关数据仍较少。本研究报告了 24 例 POEMS 综合征患者的甲状腺功能及临床表现，并对甲状腺功能减退症与水肿/渗出之间的关系进行了相关性分析。24 例 POEMS 综合征患者中，17 例（70.8%）存在明确的甲状腺功能减退症（包括 11 例临床甲状腺功能减退症和 6 例亚临床甲状腺功能减退症）。14 例（58.3%）存在某种形式的血管外容量超负荷。在 14 例存在水肿/渗出的患者中，12 例被诊断为甲状腺功能减退症。甲状腺功能减退症可能是导致水肿/渗出的原因之一。经甲状腺激素治疗和化疗后，甲状腺功能减退症和水肿/渗出的症状均得到明显改善。
