尿生物标志物表明，雌激素-DNA 加合物可能在非霍奇金淋巴瘤的病因学中发挥作用。
Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma.
机构信息
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
出版信息
Biomarkers. 2009 Nov;14(7):502-12. doi: 10.3109/13547500903121715.
Abstract
A variety of evidence suggests that estrogens may induce non-Hodgkin lymphoma (NHL). The reaction of catechol estrogen quinones with DNA to form depurinating estrogen-DNA adducts is hypothesized to initiate this process. These adducts are released from DNA, shed from cells into the bloodstream and excreted in urine. The aim of this study was to determine whether or not the depurinating estrogen-DNA adducts might be involved in the aetiology of human NHL. Estrogen metabolites, conjugates and depurinating DNA adducts were identified and quantified in spot urine samples from 15 men with NHL and 30 healthy control men by using ultraperformance liquid chromatography/tandem mass spectrometry. The levels of estrogen-DNA adducts were significantly higher in the men with NHL than in the healthy control men. Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk.
摘要
多种证据表明雌激素可能会诱发非霍奇金淋巴瘤（NHL）。儿茶酚雌激素醌与 DNA 反应形成致脱嘌呤雌激素-DNA 加合物，这被假设是引发该过程的原因。这些加合物从 DNA 中释放出来，从细胞中脱落到血液中，并从尿液中排出。本研究旨在确定致脱嘌呤雌激素-DNA 加合物是否可能参与人类 NHL 的病因。通过使用超高效液相色谱/串联质谱法，在 15 名 NHL 男性患者和 30 名健康男性对照者的尿液样本中鉴定和定量了雌激素代谢物、缀合物和致脱嘌呤 DNA 加合物。NHL 男性患者的雌激素-DNA 加合物水平明显高于健康对照组男性。因此，雌激素-DNA 加合物的形成可能在 NHL 的病因学中起关键作用，并且这些加合物可能是非霍奇金淋巴瘤风险的潜在生物标志物。
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