Frazzi Raffaele, Tigano Marco
Translational Research Laboratory, Department of Research and Statistics, IRCCS Arcispedale S.Maria Nuova, 42123 Reggio Emilia, Italy.
Int J Mol Sci. 2014 Mar 20;15(3):4977-93. doi: 10.3390/ijms15034977.
Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.
淋巴瘤和白血病对人类健康和预期寿命构成严重威胁。白藜芦醇是天然来源的化学预防分子中最有效且研究较多的一种。本文综述并讨论了由白藜芦醇引发或与之相关的细胞死亡的主要机制。主要聚焦于淋巴瘤和白血病的实验模型，在这些模型中，白藜芦醇已在细胞、分子或生理水平上进行了测试和研究。还报告并分析了涉及白藜芦醇的最相关的体内挑战，以确定这种多酚的关键特性以及治疗血液肿瘤的潜力。
