Computational Biology Lab, Department of Zoology, JN Vyas University, Jodhpur, Rajasthan, India.
Int J Neurosci. 2009;119(11):1995-2016. doi: 10.1080/00207450903139788.
Micro RNAs (miRNAs) are endogenous noncoding RNAs that are important for gene regulation. This review provides an overview of miRNA biogenesis and mechanism of action. The review focuses on studies relating to the spatial and temporal regulation of gene expression in neurons. Studies have shown that while some miRNA are expressed during neuronal differentiation, others are expressed only in mature neurons or synapses. This review includes reports that associate miRNA dysfunction with neurodegenerative disorders. Finally, the review raises points that may be helpful for researchers in exploring areas that have remained unanswered vis-à-vis the biogenesis and regulatory roles of miRNAs.
微 RNA（miRNAs）是内源性非编码 RNA，对于基因调控非常重要。这篇综述提供了 miRNA 生物发生和作用机制的概述。综述重点关注与神经元中基因表达的时空调节相关的研究。研究表明，虽然一些 miRNA 在神经元分化过程中表达，但其他 miRNA 仅在成熟神经元或突触中表达。本综述包括与 miRNA 功能障碍与神经退行性疾病相关的报告。最后，该综述提出了一些观点，这些观点可能有助于研究人员探索 miRNA 生物发生和调控作用方面尚未解决的问题。
