Joyner Andrea B, Runowicz Carolyn D
Carole & Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Obstetrics & Gynecology, Farmington, CT 05030, USA.
Womens Health (Lond). 2009 Nov;5(6):693-9. doi: 10.2217/whe.09.65.
One of the most challenging issues in gynecologic oncology is the high mortality rate of ovarian cancer, largely due to detection of disease in advanced stages. Women with early-stage disease have a significantly improved survival rate and may not require chemotherapy. Thus, the issues to examine are whether there are methods to improve early detection, thereby resulting in a reduction in mortality. Several large, randomized, clinical trials have recently completed evaluating CA 125 and transvaginal sonography as effective strategies to accomplish this goal. These issues and the results of the recent trials will be reviewed in this article.
妇科肿瘤学中最具挑战性的问题之一是卵巢癌的高死亡率，这主要是由于疾病在晚期才被发现。早期疾病的女性生存率显著提高，可能不需要化疗。因此，需要研究的问题是是否有方法可以改善早期检测，从而降低死亡率。最近有几项大型随机临床试验完成了对CA 125和经阴道超声作为实现这一目标的有效策略的评估。本文将对这些问题和近期试验的结果进行综述。
