Center of Excellence in Behavior Genetics, Department of Psychology, Abo Akademi University, Turku, Finland.
BJU Int. 2010 Jun;105(12):1698-704. doi: 10.1111/j.1464-410X.2009.09040.x. Epub 2009 Oct 26.
To investigate temporal continuity in ejaculatory dysfunction by comparing self-reported experiences of premature ejaculation (PE) at first intercourse with self-reported PE and delayed ejaculation at present, and to clarify whether and to what extent genetic or environmental factors affect continuity in ejaculatory dysfunction, as previous studies indicate moderate heritability for PE at first intercourse.
The study comprised retrospective self-reported data on ejaculatory performance at first sexual intercourse and a concurrent self-report of the same at the time of data collection in a population-based sample of 2633 Finnish twins and their siblings aged 18-48 years (mean 26.63, sd 4.68). The continuity of ejaculatory function was assessed by correlation and multiple regression. Reasons for continuity were separated into genetic and environmental sources using twin-model fitting.
Ejaculatory function, particularly PE, was stable over time. Genetic effects accounted for approximately 30% of the variance in PE both at first intercourse and when measured at data collection. Unshared environmental effects accounted for most of the variance ( approximately 70%). Genetic effects were almost identical between the sample occasions, but there was a substantial discrepancy between unshared environmental effects affecting PE at first intercourse and unshared environmental effects affecting PE later in life. Age effects were generally negligible. Data were self-reported and retrospective, and thus vulnerable to response bias.
Ejaculatory dysfunction seems to be temporally stable both in the short and long term. Genes that contribute to the variance in PE at first intercourse are similar to those that contribute to the variance in PE later in life, whereas there are, in this regard, substantial differences in the unshared environmental factors that are a cause of PE.
通过比较首次性交时报告的早泄（PE）经历与目前报告的 PE 和延迟射精，研究射精功能障碍的时间连续性，并阐明遗传或环境因素是否以及在何种程度上影响射精功能障碍的连续性，因为之前的研究表明首次性交时的 PE 具有中度遗传性。
本研究包括对 2633 名芬兰双胞胎及其 18-48 岁（平均 26.63，标准差 4.68）的兄弟姐妹的人口基础样本中首次性行为时的射精表现的回顾性自我报告数据，以及在数据收集时的相同自我报告。通过相关性和多元回归评估射精功能的连续性。使用双胞胎模型拟合将连续性的原因分为遗传和环境来源。
射精功能，特别是 PE，随时间稳定。遗传效应约占首次性交和数据收集时测量的 PE 方差的 30%。不可共享的环境效应占大部分方差（约 70%）。样本时的遗传效应几乎相同，但影响首次性交时 PE 的不可共享环境效应与影响以后生活中 PE 的不可共享环境效应之间存在很大差异。年龄效应通常可以忽略不计。数据是自我报告和回顾性的，因此容易受到反应偏差的影响。
射精功能障碍在短期和长期内似乎都是时间稳定的。导致首次性交时 PE 变异的基因与导致以后生活中 PE 变异的基因相似，但在导致 PE 的不可共享环境因素方面存在很大差异。
