比较遗传学在乳腺癌预防策略中的应用。
The utility of comparative genetics to inform breast cancer prevention strategies.
机构信息
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
Genetics. 2009 Oct;183(2):409-12. doi: 10.1534/genetics.109.108480.
Abstract
My research seeks to aid in developing approaches to prevent breast cancer. This research evolved from our early empirical studies for discovering natural compounds with anticancer activities, coupled with clinical evaluation to a genetics-driven approach to prevention. This centers on the use of comparative genomics to discover risk-modifying alleles that could help define population and individual risk and also serve as potential prevention drugable targets to mitigate risk. Here, we initially fine map mammary cancer loci in a rat carcinogenesis model and then evaluate their human homologs in breast cancer case-control association studies. This approach has yielded promising results, including the finding that the compound rat QTL Mcs5a's human homologous region was associated with breast cancer risk. These and related findings have the potential to yield advancements both in translation-prevention research and in basic molecular genetics.
摘要
我的研究旨在探索预防乳腺癌的方法。这项研究是从我们早期的实证研究发展而来的，旨在发现具有抗癌活性的天然化合物，并结合临床评估，采用遗传学驱动的方法进行预防。这一方法的核心是利用比较基因组学来发现能够帮助确定人群和个体风险的风险修饰等位基因，同时也可以作为潜在的预防药物靶点来降低风险。在这里，我们首先在大鼠致癌模型中精细定位乳腺癌的基因座，然后在乳腺癌病例对照关联研究中评估它们在人类中的同源物。这种方法已经取得了有希望的结果，包括发现化合物大鼠 QTL Mcs5a 的人类同源区域与乳腺癌风险相关。这些和相关的发现有可能在转化预防研究和基础分子遗传学方面取得进展。
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