Manning Jeremy R, Jacobs Joshua, Fried Itzhak, Kahana Michael J
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Neurosci. 2009 Oct 28;29(43):13613-20. doi: 10.1523/JNEUROSCI.2041-09.2009.
A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2-150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations.
神经科学中的一个基本问题涉及单个神经元的放电与局部场电位（LFP）中所见神经元群体的总体电活动之间的关系。由于局部场电位既反映放电活动又反映阈下事件，所以这个问题不仅仅是数据汇总的问题。我们对20名神经外科患者进行记录，直接研究了局部场电位与神经元放电之间的关系。通过检查广泛脑区的2030个神经元，我们发现放电率与局部场电位功率谱中的宽带（2 - 150赫兹）变化呈正相关。相比之下，窄带振荡在不同记录位点与放电率的相关性既有正相关也有负相关。宽带功率变化比窄带功率变化更能可靠地预测神经元放电。这些发现表明，宽带局部场电位功率提供了有关神经元活动的有价值信息，其超出了窄带振荡所包含的信息。
