Rosen A A, Iseri O, Fishbein G, Knodell R G
Department of Pathology, University of Maryland School of Medicine, Baltimore.
Am J Gastroenterol. 1991 Jan;86(1):86-8.
Tender hepatomegaly and ascites occurred in a young woman receiving cytosine arabinoside and daunorubicin for acute myelogenous leukemia. Whereas veno-occlusive disease was suspected clinically, liver biopsy showed nodular regenerative hyperplasia with no evidence of hepatic vein abnormalities. It is postulated that nodular regenerative hyperplasia can be initiated by hepatotoxicity of chemotherapy agents used to treat leukemia and/or that these agents exacerbate clinical manifestations of this histological abnormality. Nodular regenerative hyperplasia should be added to the list of liver problems occurring in patients with leukemia.
一名年轻女性在接受阿糖胞苷和柔红霉素治疗急性髓性白血病时出现肝肿大伴压痛及腹水。临床怀疑为肝静脉闭塞性疾病，但肝脏活检显示为结节性再生性增生，未发现肝静脉异常证据。据推测，结节性再生性增生可能由用于治疗白血病的化疗药物的肝毒性引发，和/或这些药物会加重这种组织学异常的临床表现。结节性再生性增生应被列入白血病患者出现的肝脏问题清单中。
