动态动力学拆分在手性联芳[4]和[5]螺[芴]醌的不对称合成中的应用。
Dynamic kinetic resolution in the asymmetric synthesis of atropisomeric biaryl[4] and [5]helicene quinones.
机构信息
Departamento de Química Orgánica (C-I), Universidad Autónoma de Madrid, 28049-Madrid, Spain.
出版信息
Chem Commun (Camb). 2009 Nov 21(43):6652-4. doi: 10.1039/b907653k. Epub 2009 Sep 25.
DOI:10.1039/b907653k
PMID:19865680
Abstract
Total control of axial and helical chirality elements of a (2-biphenyl)-substituted tetrahydro[5]helicene quinone and the configurationally stable dihydro[4]helicene analogue was achieved in a dynamic kinetic resolution process of an axially chiral racemic diene promoted by an enantiopure sulfinyl benzoquinone.
摘要
通过手性亚砜苯醌对轴手性外消旋二烯的动态动力学拆分反应，实现了（2-联苯）取代四氢[5]螺[芴-9,1'-环己烯]醌及其构型稳定的二氢[4]螺[环戊二烯]类似物的轴向和螺旋手性元素的完全控制。
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