Groeneveld E, Westhuizen B v D, Maiwashe A, Voordewind F, Ferraz J B S
Friedrich Loeffler Institute, Department of Animal Breeding and Genetic Resources, Neustadt, Germany.
Genet Mol Res. 2009 Sep 29;8(3):1158-78. doi: 10.4238/vol8-3gmr648.
Genetic variation provides a basis upon which populations can be genetically improved. Management of animal genetic resources in order to minimize loss of genetic diversity both within and across breeds has recently received attention at different levels, e.g., breed, national and international levels. A major need for sustainable improvement and conservation programs is accurate estimates of population parameters, such as rate of inbreeding and effective population size. A software system (POPREP) is presented that automatically generates a typeset report. Key parameters for population management, such as age structure, generation interval, variance in family size, rate of inbreeding, and effective population size form the core part of this report. The report includes a default text that describes definition, computation and meaning of the various parameters. The report is summarized in two pdf files, named Population Structure and Pedigree Analysis Reports. In addition, results (e.g., individual inbreeding coefficients, rate of inbreeding and effective population size) are stored in comma-separate-values files that are available for further processing. Pedigree data from eight livestock breeds from different species and countries were used to describe the potential of POPREP and to highlight areas for further research.
遗传变异为种群的遗传改良提供了基础。为尽量减少品种内和品种间的遗传多样性丧失而进行的动物遗传资源管理，近来在不同层面受到了关注，比如品种、国家和国际层面。可持续改良与保护计划的一个主要需求是对种群参数进行准确估计，例如近亲繁殖率和有效种群大小。本文介绍了一个能自动生成排版报告的软件系统（POPREP）。种群管理的关键参数，如年龄结构、世代间隔、家系大小方差、近亲繁殖率和有效种群大小，构成了该报告的核心部分。报告包含一段默认文本，描述了各种参数的定义、计算方法和意义。该报告总结在两个名为“种群结构”和“系谱分析报告”的pdf文件中。此外，结果（如个体近亲繁殖系数、近亲繁殖率和有效种群大小）存储在逗号分隔值文件中，可供进一步处理。来自不同物种和国家的八个家畜品种的系谱数据被用来描述POPREP的潜力，并突出进一步研究的领域。
