Institute of Neurobiology, University of Göteborg, Göteborg, Sweden.
J Cell Biol. 1970 Nov 1;47(2):319-31. doi: 10.1083/jcb.47.2.319.
Freehand, isolated neuronal perikarya from the hypoglossal nucleus of the rabbit have been examined with light-and electron-microscopy (transmission and scanning). The surface of the cell bodies was largely covered with spherical particles which were 0.5-2 micro in diameter. Transmission electron microscopy proved that the spherical particles were synaptic nerve terminals. Crush of the hypoglossal nerve which leads to chromatolysis and swelling of the neuronal cell bodies results in a conspicuous reduction in the number of terminals attached to the surface of hypoglossal neurons. This effect was observed both for isolated neurons and in tissue sections. The effect is considered in relation to earlier reported variations in the adherence of neuropil to isolated neuronal perikarya. The functional importance of nerve ending detachment in connection with nerve injury is discussed.
已用光镜和电镜(透射和扫描)检查了游离的兔舌下神经核单个神经元的胞体。胞体表面大部分覆盖着直径为 0.5-2 微米的球形颗粒。电镜证明这些球形颗粒是突触神经末梢。舌下神经的压榨导致神经元细胞体的解体和肿胀,导致附着在舌下神经元表面的末梢数量明显减少。这种效应在游离神经元和组织切片中都观察到。该效应与先前报道的神经胶质与游离神经元胞体的附着变化有关。本文讨论了与神经损伤有关的神经末梢脱离的功能重要性。