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眼外运动神经元与神经营养。

Extraocular Motoneurons and Neurotrophism.

机构信息

Departamento de Fisiología, Universidad de Sevilla, Seville, Spain.

Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.

出版信息

Adv Neurobiol. 2022;28:281-319. doi: 10.1007/978-3-031-07167-6_12.

DOI:10.1007/978-3-031-07167-6_12
PMID:36066830
Abstract

Extraocular motoneurons are located in three brainstem nuclei: the abducens, trochlear and oculomotor. They control all types of eye movements by innervating three pairs of agonistic/antagonistic extraocular muscles. They exhibit a tonic-phasic discharge pattern, demonstrating sensitivity to eye position and sensitivity to eye velocity. According to their innervation pattern, extraocular muscle fibers can be classified as singly innervated muscle fiber (SIF), or the peculiar multiply innervated muscle fiber (MIF). SIF motoneurons show anatomical and physiological differences with MIF motoneurons. The latter are smaller and display lower eye position and velocity sensitivities as compared with SIF motoneurons.

摘要

眼外运动神经元位于三个脑干核团

展神经、滑车神经和动眼神经。它们通过支配三对拮抗肌和协同肌来控制所有类型的眼球运动。它们表现出紧张-相放电模式,显示出对眼位置和眼速度的敏感性。根据其神经支配模式,眼外肌纤维可分为单神经支配肌纤维(SIF)或特殊的多神经支配肌纤维(MIF)。SIF 运动神经元与 MIF 运动神经元在解剖和生理上存在差异。后者较小,与 SIF 运动神经元相比,对眼位置和速度的敏感性较低。

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Extraocular Motoneurons and Neurotrophism.眼外运动神经元与神经营养。
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引用本文的文献

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Discharge properties of morphologically identified vestibular neurons recorded during horizontal eye movements in the goldfish.在金鱼的水平眼球运动过程中记录的形态识别前庭神经元的放电特性。
J Neurophysiol. 2019 May 1;121(5):1865-1878. doi: 10.1152/jn.00772.2018. Epub 2019 Mar 20.
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Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism.外周神经损伤后脊髓运动回路的突触可塑性取决于小胶质细胞的激活和 CCR2 机制。
J Neurosci. 2019 May 1;39(18):3412-3433. doi: 10.1523/JNEUROSCI.2945-17.2019. Epub 2019 Mar 4.
3
Functional diversity of motoneurons in the oculomotor system.
眼球运动系统中运动神经元的功能多样性。
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3837-3846. doi: 10.1073/pnas.1818524116. Epub 2019 Feb 13.
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Identification of Functional Cell Groups in the Abducens Nucleus of Monkey and Human by Perineuronal Nets and Choline Acetyltransferase Immunolabeling.通过神经周网和胆碱乙酰转移酶免疫标记鉴定猴和人的展神经核中的功能细胞群
Front Neuroanat. 2018 Jun 19;12:45. doi: 10.3389/fnana.2018.00045. eCollection 2018.
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Synaptic loss and firing alterations in Axotomized Motoneurons are restored by vascular endothelial growth factor (VEGF) and VEGF-B.轴突切断运动神经元的突触丢失和放电改变可被血管内皮生长因子(VEGF)和 VEGF-B 恢复。
Exp Neurol. 2018 Jun;304:67-81. doi: 10.1016/j.expneurol.2018.03.004. Epub 2018 Mar 6.
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Palisade Endings of Extraocular Muscles Develop Postnatally Following Different Time Courses.眼外肌的栅栏状终末在出生后沿不同时间进程发育。
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5105-5121. doi: 10.1167/iovs.17-22643.
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Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons.选择性传入神经切断术对内侧直肌运动神经元放电特性的影响。
J Neurosci. 2017 Sep 20;37(38):9172-9188. doi: 10.1523/JNEUROSCI.1391-17.2017. Epub 2017 Aug 21.
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Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems.与其他脑干运动系统相比,眼球运动系统表现出更高的神经营养因子表达。
Front Neurosci. 2017 Jul 11;11:399. doi: 10.3389/fnins.2017.00399. eCollection 2017.
9
Extraocular motoneurons of the adult rat show higher levels of vascular endothelial growth factor and its receptor Flk-1 than other cranial motoneurons.成年大鼠的眼外运动神经元比其他颅运动神经元表现出更高水平的血管内皮生长因子及其受体Flk-1。
PLoS One. 2017 Jun 1;12(6):e0178616. doi: 10.1371/journal.pone.0178616. eCollection 2017.
10
Functional Organization of Vestibulo-Ocular Responses in Abducens Motoneurons.展神经运动神经元前庭眼反射的功能组织
J Neurosci. 2017 Apr 12;37(15):4032-4045. doi: 10.1523/JNEUROSCI.2626-16.2017. Epub 2017 Mar 14.