Pathological Laboratories, University of Pittsburgh, Pittsburgh, Pennsylvania.
J Exp Med. 1910 Nov 1;12(6):707-25. doi: 10.1084/jem.12.6.707.
We agree with Jores and others that not one but many factors may be at work leading to intimal hyperplasia. Among these factors may be mentioned infection, bacterial toxins, organic poisons, inflammation and increased arterial tension. The theory of Thoma that the connective tissue developed in the intima is compensatory cannot be sustained. From the evidence which we have at hand it is not possible to state that the proliferative changes in the intima are uniformly secondary to the weakening of the media. Common influences may act simultaneously upon the media and the intima. Progressive medial degeneration of the peripheral arteries (Moenckeberg's sclerosis) is the result of muscle fatigue coupled with nutritional disturbance.
我们同意 Jores 等人的观点，认为导致内膜增生的原因不是一个，而是多个因素。这些因素可能包括感染、细菌毒素、有机毒物、炎症和动脉张力增加。Thomas 认为内膜中形成的结缔组织是代偿性的，这种理论是站不住脚的。根据我们现有的证据，尚不能断言内膜的增殖性变化均继发于中膜的减弱。共同的影响可能同时作用于中膜和内膜。外周动脉的进行性中膜退行性变（Moenckeberg 硬化症）是肌肉疲劳加上营养障碍的结果。
