兔和恒河猴预先形成的免疫复合物的命运。
Fate of preformed immune complexes in rabbits and rhesus monkeys.
机构信息
Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington 98105.
出版信息
J Exp Med. 1971 Sep 1;134(3):19-31.
Preformed soluble immune complexes injected into rabbits or rhesus monkeys showed similar characteristics of disappearance from circulation. Complexes made with intact gammaG-antibodies and exceeding the Ag(2)Ab(2) lattice formation were rapidly removed by the hepatic RES. These complexes fixed complement effectively in vitro. Their hepatic uptake was not dependent upon circulating complement components, since their accumulation in the liver was unchanged in complement depleted rabbits. Similar antigen-antibody complexes made with reduced and alkylated gammaG-antibodies fixed complement ineffectively in vitro. These complexes possessed different disappearance characteristics and were not rapidly taken up by the liver, regardless of their degree of lattice formation. Both in vitro and in vivo studies failed to suggest any role for the immune adherence receptor on primate erythrocytes in the handling of circulating soluble immune complexes composed of BSA and gammaG-antibodies to this antigen.
预先形成的可溶性免疫复合物注入兔子或恒河猴体内，显示出从循环中消失的相似特征。用完整的γG 抗体和超过 Ag(2)Ab(2)晶格形成的复合物，迅速被肝 RES 清除。这些复合物在体外有效地固定补体。它们在肝内的摄取不依赖于循环补体成分，因为在补体耗尽的兔子中，其在肝内的蓄积没有变化。用还原和烷基化的γG 抗体制成的类似抗原抗体复合物在体外固定补体的效率较低。这些复合物具有不同的消失特征，并且无论晶格形成程度如何，都不会被肝脏迅速摄取。体外和体内研究均未能表明灵长类红细胞上的免疫粘附受体在处理由 BSA 和针对该抗原的γG 抗体组成的循环可溶性免疫复合物方面发挥任何作用。
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