Laboratories and Hospital of The Rockefeller Institute for Medical Research, New York.
J Exp Med. 1913 May 1;17(5):587-92. doi: 10.1084/jem.17.5.587.
The reduction of the oxygen capacity which occurs after incubating pneumococcus cultures with washed rabbit corpuscles is due to the formation of methemoglobin (or some derivative of hemoglobin with identical optical constants for three regions in the spectrum). The substance which induces the change is also present in the sterile filtrate of autolyzed cultures. By analogy we feel justified in concluding that the mechanism of the reduction of the oxygen capacity in human lobar pneumonia is at least in part of the same nature. To determine the frequency and intensity of the phenomenon in lobar pneumonia, and thereby to establish its clinical significance, is the next step and a problem upon which we are now engaged.
经洗过的兔血球孵育肺炎球菌培养物后发生的氧容量减少，是由于形成正铁血红蛋白（或对光谱的三个区域具有相同光吸收常数的血红蛋白的某种衍生物）。诱导这种变化的物质也存在于自溶培养物的无菌滤液中。根据类推，我们有理由认为，人类大叶性肺炎中氧容量减少的机制至少在部分上是相同的。为了确定此现象在大叶性肺炎中的频率和强度，从而确定其临床意义，是下一步和我们现在正在从事的问题。
