Hospital of The Rockefeller Institute for Medical Research, New York.
J Exp Med. 1913 Jul 1;18(1):1-6. doi: 10.1084/jem.18.1.1.
In rabbits with a severe pneumococcus bacteremia, the oxygen-combining power of the blood falls progressively up to the time of death. Coincident with this there is an even more marked fall in the oxygen content of the arterial blood. The changes in the blood in infected animals are analogous to those seen when the pneumococcus is grown on blood in vitro. They are due to the conversion of hemoglobin into methemoglobin.
在患有严重肺炎球菌菌血症的兔子中，血液的氧结合能力会逐渐下降，直至死亡。与此相伴的是，动脉血氧含量甚至更为显著地下降。感染动物血液中的变化与在体外血液中培养肺炎球菌时所见的变化相似。这些变化是由于血红蛋白转化为高铁血红蛋白所致。
