结核杆菌发酵抑制剂的研究：发酵作用的研究. 十一。
FERMENT-INHIBITING SUBSTANCES IN TUBERCLE BACILLI : STUDIES ON FERMENT ACTION. XI.
机构信息
Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York.
出版信息
J Exp Med. 1914 Mar 1;19(3):251-8. doi: 10.1084/jem.19.3.251.
Abstract
- Tubercle bacilli contain unsaturated fatty acids which, when saponified, have the property of inhibiting the action of trypsin and leucoprotease. 2. In proportion to their iodin value these soaps are more active as inhibiting agents than the soaps prepared from linseed, olive, and cod-liver oils. 3. The activity of the soaps is dependent on the presence of unsaturated carbon bonds. 4. Saturation of the soaps with iodin destroys their inhibiting action. 5. Soaps probably play an important part in the production of the condition known as caseation in tuberculosis.
摘要
结核分枝杆菌含有不饱和脂肪酸，这些脂肪酸经皂化后具有抑制胰蛋白酶和亮氨酸蛋白酶作用的特性。
与亚麻籽油、橄榄油和鱼肝油制成的皂相比，这些含碘皂作为抑制剂的活性更强，其活性与存在不饱和碳键有关。
按其碘值计算，这些肥皂作为抑制剂的活性比由亚麻籽油、橄榄油和鱼肝油制成的肥皂更强。
肥皂的抑制作用取决于不饱和碳键的存在。
肥皂可能在结核病中称为干酪样坏死的病症的产生中起着重要作用。
碘饱和会破坏肥皂的抑制作用。
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J Exp Med. 1914 Mar 1;19(3):239-50. doi: 10.1084/jem.19.3.239.
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