First Medical Clinic of the Imperial University in Kyushu, Fukuoka.
J Exp Med. 1916 Nov 1;24(5):485-96. doi: 10.1084/jem.24.5.485.
Horses immunized with cultures of Spirochaeta icterohaemorrhagiae yield an immune serum having therapeutic properties. With rare exceptions the serum destroys completely the spirochetes contained in the circulating blood. The development of antibodies is promoted by the serum injections. The number of spirochetes in the organs is reduced by the treatment. Secondary manifestations due to the serum are slight and disappear promptly. The ultimate effects of the serum treatment on the symptoms and final outcome of the disease have still to be determined.
用黄疸出血性蛇形螺旋体培养物免疫的马匹产生具有治疗性质的免疫血清。血清除极个别情况外,可完全破坏循环血液中的螺旋体。血清注射可促进抗体的产生。该疗法可减少器官中的螺旋体数量。血清引起的继发症状轻微,并迅速消失。血清治疗对疾病的症状和最终结果的最终影响仍有待确定。