George Williams Hooper Foundation for Medical Research of the University of California Medical School, San Francisco.
J Exp Med. 1917 Feb 1;25(2):231-53. doi: 10.1084/jem.25.2.231.
The intoxication which develops as the result of a simple obstruction or a closed intestinal loop is accompanied by definite changes in the coagulable proteins of the blood serum. These changes consist essentially in an alteration in the normal albumin-globulin ratio; the globulin fraction is greatly increased and at times the normal relation of the two fractions may show a complete inversion. The increase in the globulin content of the blood serum is most marked in the animals which show some of the complications met with in loop animals,-rupture of the loop and peritonitis. In the latter conditions especially, the globulin increase is rapid and large. We believe this reaction to be of diagnostic value in acute infections attended by the sudden liberation and absorption of a toxic exudate. Infections and intoxications produced by inflammatory irritants are also accompanied by a rise in the blood globulins. This observation suggests that tissue disintegration with absorption of toxic products is responsible for the changes noted, and that bacterial invasion is important only in as far as it gives rise to toxic substances. Animals which have developed a tolerance to proteose intoxication following the periodic injection of small doses of proteose do not show a globulin increase. These experiments do not support the view that the rise in globulins observed in these experimental conditions is an expression of a resistance or tolerance developed by the animal. From the experimental evidence it seems more probable that the alteration in the partition of the blood protein fractions is one of the results of the metabolic disturbance which has been shown to occur in these conditions.
由于单纯性肠梗阻或闭襻性肠梗阻而引起的中毒，伴有血清可凝固蛋白质的明确变化。这些变化实质上是正常白蛋白-球蛋白比值的改变；球蛋白部分大大增加，有时两个部分的正常关系可能完全颠倒。血清球蛋白含量的增加在显示闭襻动物某些并发症的动物中最为明显，如闭襻破裂和腹膜炎。在后一种情况下，球蛋白的增加特别迅速和明显。我们认为这种反应在伴有毒性渗出物突然释放和吸收的急性感染中具有诊断价值。由炎症刺激物引起的感染和中毒也伴有血液球蛋白的升高。这一观察表明，组织崩解伴有毒产物的吸收是引起所观察到的变化的原因，而细菌入侵仅在其产生毒性物质方面很重要。在周期性注射小剂量蛋白胨后对蛋白胨中毒产生耐受性的动物不会出现球蛋白增加。这些实验不支持在这些实验条件下观察到的球蛋白升高是动物产生的抗性或耐受性的表现的观点。根据实验证据，似乎更有可能的是，血液蛋白质部分的划分的改变是已经证明在这些情况下发生的代谢紊乱的结果之一。
