不易致敏性和过敏休克。
INSUSCEPTIBILITY TO SENSITIZATION AND ANAPHYLACTIC SHOCK.
机构信息
Laboratories of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1922 Nov 30;36(6):627-43. doi: 10.1084/jem.36.6.627.
Abstract
- Attempts to produce anaphylactic shock in white rats by second intravenous or subdural injections of horse serum have failed. 2. It was impossible to demonstrate either by skin reactions or by the uterine reaction that white rats can be sensitized to horse serum. 3. It was not possible to sensitize guinea pigs passively with the serum of white rats presumably immunized to horse serum. 4. In spite of the fact that the white rat could not be made anaphylactic to horse serum, the tissues of the animal reacted with the horse serum to form precipitins in fair concentration and the antigen disappeared from the circulation soon after the precipitins reached their greatest concentration in the blood. 5. These experiments would indicate that in the white rat anaphylaxis and precipitin formation are independent and represent different types of immunological processes.
摘要
通过第二次静脉或硬膜下注射马血清来诱发大白鼠过敏休克的尝试都失败了。
通过皮肤反应或子宫反应都无法证明大白鼠可以对马血清产生致敏。
用可能对白鼠血清产生免疫的血清对豚鼠进行被动致敏也是不可能的。
尽管事实上大白鼠不能对马血清产生过敏反应，但动物的组织与马血清反应，形成相当浓度的沉淀素，并且抗原在沉淀素在血液中达到最大浓度后不久就从循环中消失。
这些实验表明，在大白鼠中，过敏反应和沉淀素形成是独立的，代表不同类型的免疫过程。
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