酸性品红的反向选择抑菌作用。

THE REVERSE SELECTIVE BACTERIOSTATIC ACTION OF ACID FUCHSIN.

Laboratory of Bacteriology of the State College of Washington, Pullman.

J Exp Med. 1924 Mar 31;39(4):613-24. doi: 10.1084/jem.39.4.613.

Abstract

The reverse selective action attributed to acid fuchsin can be explained on the basis of spore resistance. This action does not apply to the vegetative cells of Gram-positive spore bearers. It cannot be extended to include the Gram-negative spore bearers. 2. The selective action of acid fuchsin is that of an ordinary weak disinfectant and is not comparable to the selective action of the triphenylmethane dyes. 3. A lack of parallelism between the bactericidal and bacteriostatic action of acid fuchsin can be explained on the basis of spore resistance and it does not exist when spores are excluded. 4. Acid fuchsin is a weaker disinfectant than basic fuchsin for both Gram-negative and Gram-positive bacteria. The process of sulfonation by which acid fuchsin is made from basic fuchsin results in a reduction in the bactericidal action of the dye for Gram-negative and Gram-positive bacteria. 5. The most significant fact in the action of the dyes on bacteria is the toxic effect of the triphenylmethane dyes on Gram-positive spore-bearing organisms.

摘要

酸复红的反向选择作用可以用孢子抗性来解释。这种作用不适用于革兰氏阳性孢子携带者的营养细胞。它不能扩展到包括革兰氏阴性孢子携带者。
酸复红的选择作用是一种普通的弱消毒剂，不能与三苯甲烷染料的选择作用相媲美。
酸复红的杀菌和抑菌作用之间缺乏平行性，可以用孢子抗性来解释，当孢子被排除在外时，这种作用就不存在了。
酸复红对于革兰氏阴性菌和革兰氏阳性菌来说，都是一种比碱性复红弱的消毒剂。酸复红是由碱性复红磺化制成的，这一过程导致染料对革兰氏阴性菌和革兰氏阳性菌的杀菌作用降低。
染料对细菌作用的最重要事实是三苯甲烷染料对革兰氏阳性孢子携带者的毒性作用。