Laboratories of the U. S. Army Medical School, Washington, D.C.
J Exp Med. 1926 Sep 30;44(4):539-51. doi: 10.1084/jem.44.4.539.
Nasopharyngeal washings from a case of epidemic influenza have proven capable of initiating a pathological change in rabbits and in guinea pigs characterized after an incubation period of 1 or 2 days, by some elevation of temperature, reduction in the number of circulating leucocytes, especially of the mononuclears, and by a pulmonary lesion during the period of reaction, which is distinguishable from those accidentally incurred at the time of death. From one such animal, in the second passage of the virus, an anaerobic coccobacius, corresponding in all respects to Bact. pneumosintes, was isolated by the method employed by Olitsky and Gates. This organism also proved capable of initiating the pathological change in animals found after inoculation with influenzal material. The observation of Olitsky and Gates that the presence of this organism in the lungs of experimental animals predisposes to pulmonary localization of other bacteria with the production of definite pneumonic lesions has been confirmed. Bact. pneumosintes infections may be induced by subcutaneous injection of infected material.
从一例流感流行的鼻咽冲洗液中，已经证明可以在接种后 1 或 2 天的潜伏期内引起家兔和豚鼠的病理变化，其特征是体温升高、循环白细胞减少，特别是单核细胞减少，以及反应期间的肺部病变，这与死亡时偶然发生的病变不同。从这样的动物中，通过 Olitsky 和 Gates 所采用的方法，从病毒的第二次传代中分离出一种厌氧球杆菌，它在所有方面都与肺炎支原体相对应。该生物体也被证明能够在家兔接种流感物质后引发动物的病理变化。Olitsky 和 Gates 的观察结果表明，这种生物体在实验动物肺部的存在使其他细菌更容易在肺部定位，并产生特定的肺炎病变，这一结果已经得到证实。肺炎支原体感染可通过皮下注射感染材料诱导。
