Department of Surgery and the Laboratory of Physiological Chemistry, Yale University, New Haven.
J Exp Med. 1927 Jun 30;46(1):27-41. doi: 10.1084/jem.46.1.27.
The effects of the ingestion of diets containing different concentrations of protein on the remaining kidney in adult white rats after a unilateral nephrectomy has been studied. In the animals on the high protein diet (85 per cent casein), actual glomerular and tubular lesions were observed in the kidneys of animals maintained for 90, 120 and 150 days after nephrectomy. In the animals on the standard ration, 18 per cent casein, no significant renal lesions were observed within the experimental period. Spontaneous focal lesions in the kidneys of rats maintained on Sherman's diets "A" and "B" were inconspicuous at the age of 350 days but became progressively more frequent and were commonly observed after 500 days. The animals on the high protein and standard rations were all under 350 days old at the completion of the experiment. It is suggested that the age factor is of importance in that young animals may have greater powers of adaptation in withstanding the injurious effect of high protein rations. The animals on the high protein ration excreted definitely larger quantities of protein in the urine, and showed a higher incidence of casts in periods roughly corresponding to those in which anatomic lesions were observed than did the rats on the standard diet.
本研究探讨了成年大白鼠单侧肾切除后，摄入不同浓度蛋白质饮食对残留肾脏的影响。在高蛋白饮食（85%酪蛋白）组的动物中，肾切除后 90、120 和 150 天，观察到动物肾脏出现实际的肾小球和肾小管病变。在标准饮食（18%酪蛋白）组的动物中，在实验期间未观察到明显的肾脏病变。用 Sherman 饮食“A”和“B”喂养的大鼠肾脏中的自发性局灶性病变在 350 日龄时不明显，但随着时间的推移，病变变得越来越频繁，在 500 日龄后普遍观察到。实验结束时，高蛋白和标准饮食组的动物均未满 350 日龄。这表明年龄因素很重要，年轻动物可能具有更大的适应能力，能够承受高蛋白饮食的有害影响。高蛋白饮食组的动物尿液中确实排出了更多的蛋白质，并且在出现形态学病变的大致对应时期，其尿中出现管型的发生率也高于标准饮食组的大鼠。
