Department of Pathology of Harvard University Medical School, Boston.
J Exp Med. 1925 Nov 30;42(6):897-904. doi: 10.1084/jem.42.6.897.
Seven groups of rats were fed on diets containing protein varying in amount from 1.36 to 40.13 per cent derived mainly from grain, casein, meat, and milk with carbohydrate, fat, and vitamines. From a number of animals one kidney was removed to double the load on the remaining one. The time of feeding was from 9 weeks to 6 months. Blood uric acid, blood urea nitrogen determinations, and microscopic examinations of the kidneys revealed no evidence of kidney damage. There was evidence of kidney hypertrophy consisting of increased weight of the kidney, large diameters of the capillary tufts, convoluted tubules, and kidneys in the animals receiving high protein diet. The nephrectomized animals that ate high protein had no kidney changes save hypertrophy and this amounted to an increase in weight of an average of 0.54 gm. or 85 per cent of the average weight of the right kidneys of the controls.
七组大鼠分别用主要来源于谷物、干酪素、肉和奶的蛋白质含量不同的饲料喂养，这些饲料中蛋白质的含量从 1.36%到 40.13%不等，同时还包含碳水化合物、脂肪和维生素。从部分动物身上取下一个肾脏，使剩下的一个肾脏的负担增加一倍。喂养时间从 9 周到 6 个月不等。血液尿酸、血液尿素氮测定以及肾脏的显微镜检查均未发现肾脏损伤的证据。在接受高蛋白饮食的动物中，存在肾脏肥大的证据，包括肾脏重量增加、毛细血管丛、曲管和肾脏的大直径。接受高蛋白饮食的肾切除动物除了肥大之外没有其他肾脏变化，平均重量增加了 0.54 克，或者说是对照组右肾平均重量的 85%。
